IndraLab

Statements

SCN8A activates DNA Damage. 6 / 6
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"One study compared DNA damage induced by a 2 MED SSR challenge after 10 consecutive daily exposure of 0.7 MED SSR with and without a UVB sunscreen containing 30ppm 5-methoxypsoralen (5-MOP) which enhances pigmentation (Young etal., 1991)."
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"MED induced DNA damage through the production of reactive oxygen species (ROS), which resulted in the phosphorylation of H2A histone family memeber X (H2AX) and the activation of the Ataxia telangiectasia mutated kinase (ATM) and p53 signaling pathways."
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"However, DNA damage can be triggered by suberythematous UV exposure [5] and Bruze et al. [6] found that dimer yield was independent of MED."
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"Indeed the data indicate that the values of the extent of DNA damage induced in volunteers with skin type II and III by 2 MED can be grouped into two well separated populations centered around UDS val[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Figure 2 (a) shows the epidermal DNA damage induced by single exposures of 0.65 MED or 2 MED SSR in skin types II and IV."
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"Figure 2 (b) shows the epidermal DNA damage induced by repeat exposures of 0.65 MED SSR in skin types II and IV when biopsies were taken immediately after the last tanning treatment dose."
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