IndraLab

Statements

SCN8A activates DNA Damage. 7 / 7
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"The present results show that MED induces DNA damage through the production of reactive oxygen species (ROS), which resulted in the phosphorylation of H2AX and the activation of the Ataxia telangiectasia mutated kinase (ATM) and p53 signaling pathways."
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"Figure 2 (a) shows the epidermal DNA damage induced by single exposures of 0.65 MED or 2 MED SSR in skin types II and IV."
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"However, DNA damage can be triggered by suberythematous UV exposure [5] and Bruze et al. [6] found that dimer yield was independent of MED."
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"Figure 2 (b) shows the epidermal DNA damage induced by repeat exposures of 0.65 MED SSR in skin types II and IV when biopsies were taken immediately after the last tanning treatment dose."
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"One study compared DNA damage induced by a 2 MED SSR challenge after 10 consecutive daily exposure of 0.7 MED SSR with and without a UVB sunscreen containing 30ppm 5-methoxypsoralen (5-MOP) which enhances pigmentation (Young etal., 1991)."
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"MED induced DNA damage through the production of reactive oxygen species (ROS), which resulted in the phosphorylation of H2A histone family memeber X (H2AX) and the activation of the Ataxia telangiectasia mutated kinase (ATM) and p53 signaling pathways."
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"Indeed the data indicate that the values of the extent of DNA damage induced in volunteers with skin type II and III by 2 MED can be grouped into two well separated populations centered around UDS val[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11684455