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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to ESR1 inhibits cell cycle. 1 / 1

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reach

"There are at least two potential avenues that MCF-7 cells can use to escape from the constraints of p14ARF-p53 induced senescence based on the literature : cyclin D1 can bind to the estrogen receptor (ER) independent from cdk4/6 and stimulate proliferation XREF_BIBR, XREF_BIBR, XREF_BIBR; ER can bind to p53 and abrogate cell cycle arrest XREF_BIBR, XREF_BIBR, XREF_BIBR."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...