IndraLab

Statements

TNFAIP3 activates RIPK1. 5 / 5
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"However, molecules that negatively regulate Ripk1 and Jnk signaling, such as Tnfaip3 (A20) and GADD45beta respectively XREF_BIBR, are decreased in gammadelta T cells isolated from obese db/db mice."
20625397
eidos
"Because RIP1 is also an essential mediator of TLR-induced NF-kappaB activation73 , A20 might also modulate RIP1 through de-ubiquitylation and ubiquitylation during innate immune responses ."
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"TNFAIP3 targets receptor interacting protein 1 (RIP1) in the TNFR pathway and TNFR associated factor 6 (TRAF6) in the TLR pathway."
25379618
sparser
"The signaling pathway also has several levels of autoregulation, one of which includes the activation and association of the RIP1 and IκB kinases by the A20 ubiquitin-editing protein complex [ xref ]."
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"The activation of NF-κB pathway suppresses the activation of RIPK1 and cell death mediated by at least two of its transcriptional targets, TNFAIP3 and CFLAR (CASP8 and FADD Like Apoptosis Regulator, also called c-FLIP) (54, 55)."
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