IndraLab

Statements

TNFAIP3 activates RIPK1. 4 / 4
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"However, molecules that negatively regulate Ripk1 and Jnk signaling, such as Tnfaip3 (A20) and GADD45beta respectively XREF_BIBR, are decreased in gammadelta T cells isolated from obese db/db mice."
20625397
eidos
"Because RIP1 is also an essential mediator of TLR-induced NF-kappaB activation73 , A20 might also modulate RIP1 through de-ubiquitylation and ubiquitylation during innate immune responses ."
16322747
sparser
"The signaling pathway also has several levels of autoregulation, one of which includes the activation and association of the RIP1 and IκB kinases by the A20 ubiquitin-editing protein complex [ xref ]."
22507528
reach
"A20 (TNFAIP3), TNF alpha inducible protein 3; IkappaBalpha, inhibitor of kappaB alpha subunit; IKK, IkappaB kinase; IKKK, IKK kinase; IRAK1 interleukin-1 receptor associated kinase 1; MEKK3, mitogen activated protein kinase kinase kinase 3; NF-kappaB, nuclear factor-kappaB; RIP, receptor interacting protein; TAK1, transforming growth factor-beta-activated kinase 1; TNFalpha, tumor necrosis factor alpha; TNFR, TNF receptor; TRAF2, tumor necrosis factor receptor associated factor 2."
17925009