IndraLab

Statements

P38 inhibits KCNMA1. 10 / 10
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"Inhibition of P38 and ERK MAPK stimulated BK channel activity, and prevented PGE2 inhibition; this pathway may be mediated through PKC."
25589264
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"XREF_FIG is a channel recording made in a cell attached patch showing that inhibition of ERK and p38 MAPK still increased BK channel activity in PC of the split-open CCD treated with dynasore."
23673010
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"Similar results were obtained in experiments performed in the native tissue in which inhibition of ERK and p38 MAPK increased BK channel activity in the cortical collecting duct (CCD) treated with dynasore."
23673010
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"Our data show that pirfenidone blocked p38 phosphorylation and partially rescued BK channel activity while limiting ASL volume loss after smoke exposure."
28874823
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"We confirmed the previous findings that inhibition of ERK and P38 MAPK increased BK channel activity in PC of the split-open CCDs (Data not shown) [XREF_BIBR]."
23673010
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"We have previously demonstrated that inhibition of ERK and P38 MAPK increased not only the BK channel numbers but also the channel open probability in PC of the rat CCD [XREF_BIBR]."
23673010
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"Under control conditions, BK channel activity in PC was low but increased significantly by inhibition of both ERK and P38."
17151195
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"Li and coworkers demonstrated that BK channel activity in both PCs and ICs is negatively regulated by p38 and ERK1,2."
31450703
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"Inhibition of P38 and ERK signaling were reported to stimulate BK channel activity in kidney principal cells and intercalated cells [XREF_BIBR]."
26672753
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"The inhibitory role of p38 and ERK in the regulation of K secretion has been suggested by the observations that blocking p38 and ERK increases the ROMK channel activity and BK channel activity in the CCD [XREF_BIBR, XREF_BIBR]."
18839206