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APC/C Cdh1 inhibits USP1. 2 / 2

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"In this regard, the USP1 region 295-342 constitutes a destruction motif (degron) that is required for Anaphase Promoting Complex and Cyclosome Cdh1 (APC/C Cdh1)-dependent degradation of USP1 during G1 [XREF_BIBR], which appears to be further modulated by calpains [XREF_BIBR]."

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"APC/C Cdh1 -dependent degradation of USP1 allows for PCNA monoubiquitination and subsequent recruitment of trans-lesion synthesis polymerase to UV repair sites."

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IndraLab

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APC/C Cdh1 inhibits USP1. 2 / 2

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