IndraLab

Statements

Methylated PTEN decreases the amount of PTEN. 5 / 5
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"Our results strongly suggest that CpG hypermethylation of the PTEN gene contributes to the decreased expression of PTEN during acquired resistance to gefitinib or erlotinib."
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"Hypermethylation of the PTEN promoter in somatic cells downregulates PTEN expression."
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"The hypermethylation of the PTEN promoter reduces PTEN expression and leads to overactivation of the PI3K pathway ."
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"Previous studies have shown that PTEN promoter methylation can directly reduce PTEN expression in HSCs [20, 22, 31]."
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"These results indicate that the hypermethylation of the PTEN promoter region leads to lower expression of PTEN gene in ACC cells, which aids in the development of PTEN as a molecular marker for the early diagnosis of this carcinoma."
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