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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Folate leads to the methylation of TP53. 3 / 3

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"Global DNA and p53 region specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation (Wasson et al., 2006)."

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"Global DNA and p53 region specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation."

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"Additionally, in C57BL/6 mice, maternal and post-weaning folate-deficient (0.4 mg/kg diet) diets were shown to modulate colorectal cancer development by inducing p53 promoter hypomethylation in adults and adenomatous polyposis coli (APC) promoter hypermethylation in APC offspring, respectively [55]."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Folate leads to the methylation of TP53. 3 / 3

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