IndraLab

Statements

EP300 activates MDM2. 6 / 7
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"We found that p300 and the deacetylase sirtuin 1 (SIRT1) reciprocally modulated the function of MDM2 through shared target Lys sites."
28196907
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"Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF."
17226766
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"Indeed, the fact that p300 functions to destabilize wild-type p53 in certain conditions is supported by multiple lines of evidence, including demonstration that p300 enhances MDM2 mediated destruction of p53 XREF_BIBR, XREF_BIBR."
23133622
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"Consistently, the deacetylase inhibitor, trichostatin A, did not significantly affect the half-life of the endogenous MDM2 protein, whereas p300 enhanced the half-life of MDM2."
12493762
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"A puzzling study has also shown that p300 promotes p53 turnover by recruiting mdm2 [97]."
11553416
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"Second, overexpression of p300 in cells increased the level of the MDM2 protein but not its mRNA."
12493762