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USP22 activates cell cycle. 31 / 31
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"These findings together with previous reports that PI3K and Akt signaling upregulates cyclin D2 via repression of the transcriptional factor FOXO1 [XREF_BIBR] suggest that USP22 promotes cell cycle progression possibly via PI3K/Akt/cyclin D2 pathway in ATC cells."
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"In addition, the mechanism of USP22 on promoting cell cycle progression in colorectal cancer has been reported recently, which further confirmed our results[37]."
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"Mechanistically, there is evidence that USP22 promotes cell cycle progression by increasing β-catenin nuclear localization, which is required for Wnt pathway activation."
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"USP22 has been shown to induce cell cycle progression via BMI-1 and p-Akt pathways in colorectal carcinoma [37] and promote the epithelial-mesenchymal transition (EMT) by regulating EMT marker express[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Studies have shown that overexpression of USP22 can enhance the inhibitory effect of cell cycle inhibitors such as p21 and enhance the proliferation of tumor cells, thus promoting the occurrence and development of tumors [XREF_BIBR]."
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"Our previous studies have confirmed that defects in USP22 can not only cause cell cycle arrest in G0/G1 phase, but also inhibit apoptosis and promote tumor cell proliferation [XREF_BIBR]."
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"However, the expression and functions of USP22 in pancreatic ductal adenocarcinoma (PDA) and whether FoxM1 is involved in USP22 mediated cell cycle regulation have not been studied."
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"While it is clear that USP22 is overexpressed in various cancer types and may promote oncogenesis by altering gene expression, cell death and cell cycle progression, emerging evidence suggests that USP22 also harbors tumor suppressor like properties."
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"As a consequence, gain of USP22 functions promotes cell cycle progression and inhibits cell apoptosis, leading to cancer cell hyper-proliferation and tumorigenesis."
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"USP22 depletion causes cells to accumulate in the G1 phase of the cell cycle and results in concomitant decreases in the percentage of cells in the synthesis and second gap and mitosis phases."
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"We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-beta1 (TGFB1)."
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"USP22 siRNA transfection induced cell cycle at G0/G1 phase via upregulation of p53, p21 and downregulation of cyclin E in bladder cancer cells (50)."
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"Another study also revealed that USP22 depletion reduced cell cycle progression and retarded tumor growth in animal models of bladder cancer, liver cancer, lung cancer, breast cancer and ovarian cancer (51)."
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"USP22 has been shown to promote the proliferation of human non small cell lung cancer cell H1129 and human bladder cancer cell EJ by facilitating cell cycle progression, which was supported by the observed G1 phase arrest and concomitant reduction in the S and G2/M phase when USP22 was depleted [XREF_BIBR, XREF_BIBR]."
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"Our group first demonstrated that knockdown of USP22 induces cell cycle arrest and inhibits cell growth in the HCC cell line HepG2 [ 8] ."
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"BMI-1, p16INK4a, p14ARF, cyclin D2, and c-Myc have been implicated in the regulation of the cell cycle mediated by USP22 in cell culture experiments."
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"Therefore , up-regulation of USP22 expression will lead to abnormal activation of multiple pathways to promote cell survival while down-regulation of USP22 expression can induce cell cycle arrest at G0 / G1 phase in different types of cancer cells ( Zhang et al ., 2008 ) ."
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"Previous study also showed that USP22 promotes cell cycle progression by positively regulating the PI3K and Akt pathway [XREF_BIBR]."
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"USP22 can enhance cell growth and promote cell cycle progression in some cell lines[14]."
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"First, using hormone-proficient conditions, USP22 enhanced the rate of cell cycle progression, evidenced through increased BrdU incorporation (XREF_FIG, left)."
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"Moreover, USP22 promotes cell cycle progression by regulating BMI-mediated INK4a/ARF and Akt signaling pathways [12, 32–34]."
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"USP22 regulates CCNB1 protein stability to promote cell cycle progression, as well as cancer cell growth, when it is aberrantly upregulated."
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"The observation that USP22 promotes cell cycle progression proved particularly important , as USP22 was later found to regulate crucial cell cycle regulators , including p21 , cyclin D1 and cyclin B1 ."
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"USP22 Modulates Cell Cycle Progression."
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"As CCNB1 regulates cell cycle progression by interacting with and activating CDK1 [XREF_BIBR], we asked whether USP22, which has been shown to promote cell cycle progression [XREF_BIBR], regulates CDK1 activation through CCNB1 stabilization."
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"XREF_BIBR In addition, another study demonstrated that silencing USP22 could inhibit proliferation and induce cell cycle arrest in bladder cancer cells."
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"Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest."
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"USP22 and USP2 promote cell cycle progression by stabilizing cyclins ( Shan et al., 2009; Gennaro et al., 2018 )."
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"Nevertheless, significant evidence is accumulating that indicates USP22 expression promotes cell cycle progression in certain cancer cell lines and that USP22 overexpression may enhance proliferation of cancer cells by facilitating premature transition through various cell cycle stages."
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"Therefore, reduced USP22 expression can not systematically induce cell cycle arrest and hinder cancer progression, as suggested above."
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"To further support our observation that USP22 promotes cell cycle progression and probe further into its potential role in cancer development, we first examined its function in cell proliferation."
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