IndraLab

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USP22 activates cell cycle. 25 / 25
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"Therefore , up-regulation of USP22 expression will lead to abnormal activation of multiple pathways to promote cell survival while down-regulation of USP22 expression can induce cell cycle arrest at G0 / G1 phase in different types of cancer cells ( Zhang et al ., 2008 ) ."
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"We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-beta1 (TGFB1)."
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"Therefore, reduced USP22 expression can not systematically induce cell cycle arrest and hinder cancer progression, as suggested above."
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"XREF_BIBR In addition, another study demonstrated that silencing USP22 could inhibit proliferation and induce cell cycle arrest in bladder cancer cells."
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"USP22 Modulates Cell Cycle Progression."
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"First, using hormone-proficient conditions, USP22 enhanced the rate of cell cycle progression, evidenced through increased BrdU incorporation (XREF_FIG, left)."
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"Moreover, USP22 promotes cell cycle progression by regulating BMI-mediated INK4a/ARF and Akt signaling pathways [12, 32–34]."
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"USP22 regulates CCNB1 protein stability to promote cell cycle progression, as well as cancer cell growth, when it is aberrantly upregulated."
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"Nevertheless, significant evidence is accumulating that indicates USP22 expression promotes cell cycle progression in certain cancer cell lines and that USP22 overexpression may enhance proliferation of cancer cells by facilitating premature transition through various cell cycle stages."
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"As CCNB1 regulates cell cycle progression by interacting with and activating CDK1 [XREF_BIBR], we asked whether USP22, which has been shown to promote cell cycle progression [XREF_BIBR], regulates CDK1 activation through CCNB1 stabilization."
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"BMI-1, p16INK4a, p14ARF, cyclin D2, and c-Myc have been implicated in the regulation of the cell cycle mediated by USP22 in cell culture experiments."
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"As a consequence, gain of USP22 functions promotes cell cycle progression and inhibits cell apoptosis, leading to cancer cell hyper-proliferation and tumorigenesis."
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"However, the expression and functions of USP22 in pancreatic ductal adenocarcinoma (PDA) and whether FoxM1 is involved in USP22 mediated cell cycle regulation have not been studied."
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"Previous study also showed that USP22 promotes cell cycle progression by positively regulating the PI3K and Akt pathway [XREF_BIBR]."
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"These findings together with previous reports that PI3K and Akt signaling upregulates cyclin D2 via repression of the transcriptional factor FOXO1 [XREF_BIBR] suggest that USP22 promotes cell cycle progression possibly via PI3K/Akt/cyclin D2 pathway in ATC cells."
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"To further support our observation that USP22 promotes cell cycle progression and probe further into its potential role in cancer development, we first examined its function in cell proliferation."
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"Our previous studies have confirmed that defects in USP22 can not only cause cell cycle arrest in G0/G1 phase, but also inhibit apoptosis and promote tumor cell proliferation [XREF_BIBR]."
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"The observation that USP22 promotes cell cycle progression proved particularly important , as USP22 was later found to regulate crucial cell cycle regulators , including p21 , cyclin D1 and cyclin B1 ."
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"Studies have shown that overexpression of USP22 can enhance the inhibitory effect of cell cycle inhibitors such as p21 and enhance the proliferation of tumor cells, thus promoting the occurrence and development of tumors [XREF_BIBR]."
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"Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest."
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"Gain- and loss-of-function assays showed that USP22 promoted gastric cancer cell growth and cell cycle transition while suppressing apoptosis in vitro."
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"Our group first demonstrated that knockdown of USP22 induces cell cycle arrest and inhibits cell growth in the HCC cell line HepG2 [ 8] ."
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"While it is clear that USP22 is overexpressed in various cancer types and may promote oncogenesis by altering gene expression, cell death and cell cycle progression, emerging evidence suggests that USP22 also harbors tumor suppressor like properties."
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"USP22 has been shown to promote the proliferation of human non small cell lung cancer cell H1129 and human bladder cancer cell EJ by facilitating cell cycle progression, which was supported by the observed G1 phase arrest and concomitant reduction in the S and G2/M phase when USP22 was depleted [XREF_BIBR, XREF_BIBR]."
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"USP22 depletion causes cells to accumulate in the G1 phase of the cell cycle and results in concomitant decreases in the percentage of cells in the synthesis and second gap and mitosis phases."
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