IndraLab

Statements

CYLD is sumoylated. 5 / 5
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"We observed that a short ATRA treatment of neuroblastoma causes a transient SUMOylation of CYLD that reduces its deubiquitin activity, as well as activation of NF-κB signaling via ubiquitination of TRAF2/TRAF6."
26973854
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"The SUMOylation of CYLD at the Lys40 residue of its N-terminus can also reduce its activity against substrates TRAF2 and TRAF6 ( xref ), and block the activation of NF-kB signalling, which plays an essential role in inflammatory reactions ( xref )."
34177595
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"However, prolonged ATRA treatment reduced CYLD SUMOylation and promoted cell death instead."
26973854
sparser
"Therefore, it was proposed that the balance between non-SUMOylated and SUMOylated CYLD can direct neuroblastoma cancer cells against differentiation or cell death via regulation of NF-κB signaling [ xref ]."
26973854
sparser
"SUMOylation of CYLD occurs at residue Lys40 in the N-terminus of CYLD and although it is separate from the USP domain, it is capable of inhibiting DUB activity [ xref ]."
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