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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EXXXLL motif decreases the amount of HCN1. 1 / 1

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reach

"The finding that the YXXL motif in exon 2 and EXXXLL motif in exon 5 are critical for the ability of distinct isoforms of TRIP8b to reduce HCN1 surface expression strongly supports a model in which TRIP8b acts as a bridge protein, recruiting AP-2 adaptors to TRIP8b and HCN1 channel complexes that enable the formation of clathrin coated pits and subsequent channel endocytosis."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...