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UCHL1 activates TGFB. 13 / 13
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"Here, we show that the deubiquitinating enzyme UBH-1 in Caenorhabditis elegans and its human homolog, ubiquitin C-terminal hydrolase-L1 (UCH-L1), stimulate DAF-7 and TGF-beta signaling, suggesting that this mode of regulation of TGF-beta signaling is conserved across animal species."
32371398
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"The authors showed that UBH-1 in Caenorhabditis elegans and its human homolog UCHL1 promotes DAF-7/ TGF-β signalling, indicating that the mechanism of TGF-β signalling is conserved among animal species [67]."
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"UCHL1 + exosomes upregulate TGFbeta signaling and serves as blood-based biomarker for aggressive breast cancer ."
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"Overexpression of UCH-L1, but not of UCH-L3 (the other human homolog of UBH1) or of the catalytic mutant UCH L1C90A, enhanced TGF-beta and SMAD-induced transcriptional activity, indicating that the deubiquitination activity of UCH-L1 is indispensable for enhancing TGF-beta and SMAD signaling."
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"Mechanistically , we found UCHL1 could promote the transforming growth factor-beta ( TGFbeta ) - SMAD canonical signaling pathway by protecting the cell surface TGFbeta type I receptor and its downstream intracellular effector SMAD2 from proteasomal degradation ."
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"In a contrasting analysis, Liu et al. proposed that UCHL1 promotes breast cancer metastasises by deubiquitinating and stabilising TGFβR1 and SMAD2 in TNBC by maintaining the TGF-β signalling pathway [54], with UCHL1 inhibition using a cyanpyrrolidine-based covalent inhibitor 6RK73 or genetic knockdown antagonising TGF-β signalling in TNBC models."
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"These results indicate that UCH-L1 activity supports DAF-7 and TGF-beta signaling and suggest that UCH-L1 's deubiquitination activity is a potential therapeutic target for managing lung cancer."
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"In addition, TGF-β signalling is enhanced by overexpression of UCHL1 but not the mutant UCHL1-C90A, indicating that catalytic activity of UCHL1 is mandatory for enhancing TGF-β signalling."
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"In several systems, including a zebrafish xenograft model, the authors provide evidence that exosomes enriched in UCHL1 upregulated TGF-β signalling in receptor cells via transfer from exosomes, facilitating migration and extravasation of breast cancer cells [54]."
34497382
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"Overexpression of UCH-L1, but not of UCH-L3 (the other human homolog of UBH1) or of the catalytic mutant UCH-L1 C90A, enhanced TGF-beta and SMAD-induced transcriptional activity, indicating that the deubiquitination activity of UCH-L1 is indispensable for enhancing TGF-beta and SMAD signaling."
33516505
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"Similarly, IMP-1710 could be employed as a tool to study UCHL1-mediated TGF-β signaling in non-cancer contexts, such as cardiac remodeling [99]."
34497382
reach
"These results indicate that UCH-L1 activity supports DAF-7 and TGF-beta signaling and suggest that UCH-L1 's deubiquitination activity is a potential therapeutic target for managing lung cancer."
33516505
reach
"Here, we show that the deubiquitinating enzyme UBH-1 in Caenorhabditis elegans and its human homolog, ubiquitin C-terminal hydrolase-L1 (UCH-L1), stimulate DAF-7 and TGF-beta signaling, suggesting that this mode of regulation of TGF-beta signaling is conserved across animal species."
33516505