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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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TP53 binds MDM2 and RITA. 8 / 8
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sparser
"RITA prevented p53-HDM-2 interaction in vitro and in vivo and affected p53 interaction with several negative regulators."
sparser
"If MDM2 overexpression occurs, several compounds have been developed which can block the interaction between MDM2 and p53 like RITA (reactivation of p53 and induction of tumor cell apoptosis; binds th[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"RITA prevented interaction of p53 and Mdm-2 in vitro due to p53 conformational change ( xref )."
sparser
"Based on the previous reports on the apoptotic effect of RITA on different types of solid tumors, RITA-induced apoptosis is thought to be mediated by inhibition of the p53-MDM2 interaction by binding of RITA with p53 xref , xref – xref ."
sparser
"Interfering in the MDM2p53 interaction, with small molecules like RITA and Nutlin-3, provides an attractive strategy for (re)activating wild-type p53 in a non-genotoxic way."
sparser
"Inhibition of GSK-3β activity ( xref ) or knock down of GSK-3β ( xref ) leads to upregulation of MDM2 and degradation of p53 which could not be significantly altered by addition of inhibitors of MDM2-p53 interaction, nutlin-3a or RITA ( xref )."
sparser
"Thus, the possibility that RITA binds to both p53 and MDM2 makes it an attractive lead compound for further development of potent and effective anti-cancer drugs."
sparser
"Multiple techniques have been used to probe the binding of small molecule inhibitors RITA and Nutlin-3 to N-terminal p53 (Np53) and N-terminal MDM2 (N-MDM2), respectively."