IndraLab

Statements

TP53 binds MDM2 and RITA. 9 / 9
| 9
sparser
"RITA prevented interaction of p53 and Mdm-2 in vitro due to p53 conformational change ( xref )."
24012397
sparser
"The different molecules used were Nutlin-3a and Idasanutlin, which bind to the MDM2 part and RITA, which binds to the p53 part of the MDM2–p53 complex."
35053532
sparser
"Interfering in the MDM2–p53 interaction, with small molecules like RITA and Nutlin-3, provides an attractive strategy for (re)activating wild-type p53 in a non-genotoxic way."
21509038
sparser
"Inhibition of GSK-3β activity ( xref ) or knock down of GSK-3β ( xref ) leads to upregulation of MDM2 and degradation of p53 which could not be significantly altered by addition of inhibitors of MDM2-p53 interaction, nutlin-3a or RITA ( xref )."
21738215
sparser
"Multiple techniques have been used to probe the binding of small molecule inhibitors RITA and Nutlin-3 to N-terminal p53 (Np53) and N-terminal MDM2 (N-MDM2), respectively."
26217671
sparser
"RITA prevented p53-HDM-2 interaction in vitro and in vivo and affected p53 interaction with several negative regulators."
15558054
sparser
"If MDM2 overexpression occurs, several compounds have been developed which can block the interaction between MDM2 and p53 like RITA (reactivation of p53 and induction of tumor cell apoptosis; binds th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26689115
sparser
"Based on the previous reports on the apoptotic effect of RITA on different types of solid tumors, RITA-induced apoptosis is thought to be mediated by inhibition of the p53-MDM2 interaction by binding of RITA with p53 xref , xref – xref ."
22276160
sparser
"Thus, the possibility that RITA binds to both p53 and MDM2 makes it an attractive lead compound for further development of potent and effective anti-cancer drugs."
16174299