IndraLab

Statements

TCF7 binds UCHL5. 9 / 9
4 | 4 1
sparser
"UCH37 can specifically bind and deubiquitinate transcription factor 7 (Tcf7) to activate Wnt signaling in human liver cancer cells [ xref ]."
33498168
biogrid
No evidence text available
28198400
biogrid
No evidence text available
28198400
biogrid
No evidence text available
28198400
biogrid
No evidence text available
28198400
reach
"Uch37 specifically and directly interacts with Tcf7."
28198400
reach
"Moreover, GST-pull down assay using purified recombinant Uch37 (His Uch37) and Tcf7 (GST-Tcf7) proteins demonstrated a direct interaction between Uch37 and Tcf7 (XREF_FIG)."
28198400
reach
"Having demonstrated that Uch37 is required for Wnt signalling and specifically interacts with Tcf7, we next hypothesized that Uch37 binds Tcf7 to serve as a bona fide DUB for Tcf7 protein during Wnt signalling."
28198400
reach
"Our Co-IP and GST pulldown analyses clearly demonstrated that Uch37 binds Tcf7 directly, and that the physical interaction requires the C-terminal region of Tcf7 protein that includes HMG domain and C-terminal extension."
28198400