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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 decreases the amount of TSC2. 2 / 2

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"Reciprocally, p53 negatively regulates cell growth by activating expression of Pten, TSC2, and AMPKbeta."

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"Several key components of the mTOR pathway are, in fact, down-regulated by p53 [XREF_BIBR] and, consistent with this idea, the Blagosklonny and Gudkov labs showed, in a subsequent publication [XREF_BIBR], that silencing the expression of TSC2, an upstream inhibitor of mTORC1 that is induced by p53, partially changed Nutlin 3a induced quiescence into senescence."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...