IndraLab

Statements

USP7 activates Histone. 3 / 3
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"The results of single-cell RNA-seq, RT-qPCR, western blot, and immunofluorescence staining indicated that interference with USP7 caused failure of the morula-to-blastocyst transition and was accompanied by abnormal expression of key genes (Cdx2, Oct4, Nanog, Sox2) for lineage differentiation, decreased transcript levels, increased global DNA methylation, elevated repressive histone marks (H3K27me3), and decreased active histone marks (H3K4me3 and H3K27ac)."
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"The present study evaluated whether USP7 also mediates histone acetyltransferase Tat-interactive protein 60 (Tip60) in the development of ALI inflammation."
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"Although an indirect correlation between USP7 and the metastasis of gastric cancer has been shown previously by altering the levels of USP7 mediated histone demethylase PHF8 (Li et al., 2017), our study demonstrated the direct correlation between USP7 enzyme activity and cancer cell migration ability in a p53 independent manner for the first time."
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