IndraLab

Statements

E2 activates HCN1. 4 / 4
| 4
reach
"We therefore reasoned that the GST-RAP-induced inhibition of Reelin signaling was either not sufficient to suppress the E2 induced increase of HCN1 in distal CA1 or, more generally, that Reelin is not required for the distal HCN1 enrichment in our experimental setting."
30406178
reach
"In organotypic entorhino-hippocampal cultures, we found that E2 promotes HCN1 distal dendritic enrichment via the G protein coupled estrogen receptor GPER1, but apparently independent of Reelin, because GST-RAP, known to reduce Reelin signaling, did not prevent E2 induced HCN1 enrichment in distal CA1."
30406178
reach
"Consequently, the proximal-distal HCN1 gradient, denoted by the slope from segment 1-5, was significantly increased in the presence of E2 (E2 : 6.26 +/- 0.35 vs. Ctl : 5.04 +/- 0.36, n = 21; linear regression analysis : F = 5.9, DFn = 1, DFd = 206, p = 0.016), showing that E2 had promoted the developmental enrichment of HCN1 in the CA1 distal dendritic segment (XREF_FIG)."
30406178
reach
"E2 promotes the distal dendritic enrichment of HCN1 in CA1 pyramidal cells."
30406178