IndraLab

Statements

Mutated TP53 decreases the amount of TP53. 15 / 15
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"L2DTL overexpression is associated with enhanced metastatic potential of HCC, and contributes synergistically with p53 mutation, which leads to the loss of p53 governed checkpoints, toward advanced HCC with poor prognosis."
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"Mutant p53 proteins usually causes the accumulation of p53 protein at a very high levels, and the mutant p53 protein itself can inhibit normal p53 protein levels [XREF_BIBR]."
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"Also, overexpression of epidermal growth factor receptor (EGFR) protein and mutation of the TP53 tumour suppressor gene with or without overexpression of the p53 protein are some of the genetic features of paediatric HGGs [XREF_BIBR - XREF_BIBR]."
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"In a previous study, Chang et al. ( Chang et al., 2019 ) have stated that the African-American BRIC patients are more prone to have TP53 mutations, which contribute to a decreased level of TP53’s tran[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The expression of programmed cell death ligand 1 (PD-L1), one of the preferred targets of immunotherapy, is down-regulated by mutant p53 via miR-34, thus demonstrating the involvement of p53 expression in the amplitude of the response to ICI therapy [97,98,99]."
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"Mutation of p53 K120 to R inhibits p53-mediated transcription of PUMA and BAX."
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"In heterozygous cancers (bearing mutant / wild-type allele combination), previous studies have suggested that the heterotetramization of mutant p53 with wild-type p53 can suppress the expression of th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Loss or alteration of p53 caused by TP53 mutations can regulate the recruitment and activation of immune cells, resulting in the suppression or evasion of anti-tumor immune responses [31, 32]."
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"Furthermore, in many types of human tumors, overexpression of mutant p53 is associated with a poor prognosis, supporting the idea of a gain-of-function phenotype for mutant p53, rather than a loss-of-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P53 mutations can down-regulate p53 expression, which induces tumour growth through inadequate suppression of cellular proliferation by decreased apoptosis [15] ."
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"These results indicate that missense-type p53 mutations together with loss of wild-type p53 accelerate the late stage of colorectal cancer progression through the activation of both oncogenic and inflammatory pathways."
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"Kim et al. showed that lysine382 to arginine mutation of p53 abolished p53-mediated transcription [45]."
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"Therefore, mutations of the P53 gene lead to patients with poorer survival rates for reduced expression of normal p53 protein."
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"Moreover, the mutant p53 protein itself can inhibit normal p53 protein levels."
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"However, TP53 mutants have been shown to suppress the expression of wild-type p53 targeting p21 which functions as a vital cell cycle inhibitor and causes alteration in the Cyclin and CDK complex."
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