IndraLab

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IL6 leads to the methylation of TP53. 9 / 9
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"IL-6 enriched lung cancer stem cell subpopulations could lead to the hypermethylation of p53 and p21 through DNMT1 upregulation [57] ."
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"The association between DNA methylation and cancer stage might be dependent on interleukin 6, a chronic inflammation marker that enhances the hypermethylation of tumor suppressor gene p53 families, but reduces the methylation of the epidermal growth factor receptor [XREF_BIBR]."
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"In the A549 cancer cell line, senescence-related IL-6 promotes the methylation of p53 and p21 by increasing cellular DNMT1 expression [66], which helps to suppress the weakening of the influence of necessary senescence regulatory factors and promotes the formation of a cancer stem phenotype."
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"Moreover, previous studies also showed that increased DNMT1 expression mediated by IL-6 stimulation promotes hypermethylation of p21 and p53 in lung cancer cells [50], and SOCS3 in pancreatic cancer cells [51]."
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"IL-6 also increases the promoter methylation of p53, a crucial tumor suppressor gene, resulting in decreased P53 expression by inducing the expression of DNMT1 in a human multiple myeloma cell line (71)."
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"In the A549 cancer cell line, senescence-related IL-6 promotes the methylation of p53 and p21 by increasing cellular DNMT1 expression [ xref ], which helps to suppress the weakening of the influence of necessary senescence regulatory factors and promotes the formation of a cancer stem phenotype."
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"One potential mechanism for this effect is through the activity of IL-6, which has been shown to support the aberrant methylation of the p53 promoter via up-regulation of DNMT1 gene expression."
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"For example, IL-6 increased the methylation of p53 and p21 in A549 cancer cells by expression of DNMT1 ( xref )."
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"In multiple myeloma (MM) KAS 6/1 cells, IL-6 treatment leads to TP53 promoter methylation, resulting in decreased TP53 expression levels."
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