IndraLab

Statements

USP22 increases the amount of AR. 3 / 4
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"The observations that USP22 upregulation is sufficient to promote ligand independent AR expression and activity, and induce Casodex resistance are clinically relevant, as these attributes reflect key biochemical characteristics of CRPC."
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"And correspondingly, overexpression of USP22 stabilized AR-V7 expression in a manner similar to USP14 (Fig. 5A–D), demonstrating that USP22 may also be involved in stabilizing the protein level of AR-V7, similar to USP14.In fact, the regulation of AR expression and function by USP22 in prostate cancer has been reported [37], but whether AR-V7 could be regulated by USP22 is elusive."
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"Further, USP22 mediates AR expression through a proteasome dependent mechanism, since modeling clinically-relevant USP22 upregulation results in an increased AR protein half-life and proteasome inhibition rescued the decreased AR expression following USP22 depletion."
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