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STAT3 increases the amount of MMP9. 37 / 40
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"34 In a number of other human brain tumor cell lines, stimulation with IL-6, leukemia inhibitory factor, ciliary neurotrophic factor, or OSM induced STAT3 activation, 35 and treatment of human astrogl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The enhanced activation of STAT3 in neutrophils can promote the expression and release of MMP-9, and reduce the expression of TRAIL and the release of NE [XREF_BIBR]."
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"MMP9 is an important effector molecular in STAT3 pathway [19], and STAT3 activation can increase MMP9 expression, resulting in extracellular matrix (ECM) degradation in the tumor microenvironment [20][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has also been reported that STAT3 modulates the expression of MMP-2 and MMP-9, which help in metastasis and angiogenesis."
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"STAT3 knockdown inhibited the expression of cyclin D1, cyclin D2, cyclin D3, MMP-2, and MMP-9 in both cell lines, confirming that EtOH increases the proliferation in breast cancer cells through STAT3 activation with an increased expression of cyclins and MMPs."
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"We showed that STAT3 overexpression promoted EMT (epithelial-mesenchymal transition) with increased matrix metalloproteinase (MMP)-2 and MMP9 expression."
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"In this study, we showed that p-STAT3 directly interacts with a GAS element in MMP-9 gene promoter to drive gene expression of MMP-9."
28859117
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"Suppression of JAK2 and STAT3 pathway by AG490 attenuated the promotive effects of IL-9 on SMMC-7721 cells, and reduced the expression of VEGF, MMP-2 and MMP-9."
31966644
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"Furthermore, KYZ3 inhibited TNBC cell metastasis by decreasing the levels of MMP-9 which were directly regulated by activated STAT3."
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"In addition, STAT3 activation has been demonstrated to increase the transcription of matrix metalloproteinase-9 (MMP-9), MMP-2, focal adhesion kinase (FAK) and fascin-1, which are well-known pro-invasive factors in GBs [44]."
31698775
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"P-STAT3 induces the overexpression of MMP-9 in the vascular endothelial cells leading to microvascular proliferation and BM degradation [XREF_FIG]."
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"EGF also induced the phosphorylation of EGFR, ERK, and STAT-3, and these effects were inhibited by the EGFR inhibitor, AG1478.To investigate the involvement of the STAT-3 pathway on EGF induced MMP-9 expression, we pretreatedSKBR3 cells with JAK1, JAK2, and JAK3 inhibitors prior to EGF treatment."
19385051
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"STAT3 leads to the expression of NGF, MMP2, and MMP9 in pancreatic cancer cells so that they can migrate and invade."
32555170
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"IRF-2 and IRF-1 ratio was associated with tumor invasion, probably through modulation of MMP9 expression mediated by STAT3."
22805863
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"To confirm that the expression of MMP-2 and MMP-9 was directly regulated by STAT3, we used a STAT3 targeted siRNA or a control siRNA."
29065966
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"In addition, both NF-kappaB activation and STAT3 activation were positively correlated with MMP9 in gastric cancer tissues (P = 0.001 and P = 0.022, respectively), decreased E-cadherin expression and increased Snail and MMP9 expressions in cultured cells."
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"Although STAT3 directly activates the transcription of MMP2 and MMP9 in cancer cells [21, 22], the regulatory mechanisms in alveolar macrophages should be further validated.In conclusion, IL-33 production increases in LPS-induced ALI rats and LPS-treated alveolar macrophages."
30410547
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"STAT3 inhibition with S3I-201 significantly reduced obstruction induced MMP-9 expression and tubulointerstitial fibrosis."
27760767
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"PLOD3 is thought to promote cancer metastasis by regulating STAT3, which in turn stimulates the expression of MMP-2 and MMP-9 [XREF_BIBR]."
33807594
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"Inhibition of STAT3 using an inhibitor, SH-4-54, significantly downregulated MMP-9 expression and decreased MVD and BM degradation."
32047820
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"It has been established that the transcriptions of MMP2 and MMP9 are promoted by STAT3 activation [XREF_BIBR]."
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"In conclusion, we report here that p-STAT3 directly interacts with MMP-9 gene promoter to drive gene expression of MMP-9 cells."
28859117
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"In the present study, inhibition of STAT3 decreased MMP2 and MMP9 expression, which was accompanied by reduced invasion and migration of OSCC cells."
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"Furthermore, STAT3 inhibition dramatically suppressed MMP2 and MMP9 expression in OS cell supernatants treated with ADSC conditioned medium."
28423603
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"As shown in Fig. 2 B, EGF induced EGFR, ERK, and STAT-3 phosphorylation were significantly decreased by AG1478.To investigate the involvement of STAT-3 on EGF induced MMP-9 expression, we pretreated S[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19385051
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"We also evaluated the expression levels of MMP2, MMP9 and E-cadherin in siRNA treated OS cells by western blotting, and STAT3 inhibition significantly decreased MMP2 and MMP9 expression in OS cells and increased E-cadherin expression."
28423603
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"To investigate which signaling pathway was decisive in the PFD-induced increase in the expression of MMP-2/9, we evaluated AKT, ERK, p38, SRC, FAK, and STAT3 phosphorylation levels, and found that PFD may activate the p38, FAK, STAT3, ERK, and SRC pathways to promote the expression of MMP-2 and MMP-9 proteins."
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"Furthermore, STAT3 were reported to up-regulate MMP-2 and MMP-9 expression and activities via directly binding to their promoter [XREF_BIBR - XREF_BIBR]."
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"STAT3 also upregulates MMP2, MMP9, Twist, Snail, and vimentin expression to mediate an EMT phenotype (87, 95, 111, 112) ."
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"Previous studies have demonstrated that STAT3 signaling mediated up-regulation of MMP-9 expression and conferred increased invasion ability in multi-drug-resistant breast cancer cells [XREF_BIBR]."
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"Our data suggest that blockade of STAT3 activity decreases the expression of N-cadherin, MMP2, MMP9 and VEGF, but increases the expression of E-cadherin, suggesting that STAT3 may be involved in the regulation of the expression of E-cadherin, N-cadherin, MMPs, and VEGF."
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"Since STAT3 can promote the expression of matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9), B7-H3 can regulate the expression of MMP2 and MMP9 [XREF_BIBR]."
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"The marked effect of both PYK2 shRNA and SB225002 on EGF induced SKBR invasion and MMP9 expression, led us to examine the influence of SB225002 on EGF induced phosphorylation of PYK2 as well as the phosphorylation of STAT3, AKT and ERK1/2."
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"Therefore, ERK1/2, PI3K and AKT, STAT3, and STAT5 upregulate the expression and activity of MMP-9 by mediating upstream EGF."
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"As shown in Supplementary Figure S4, silencing of STAT3 significantly decreased invasion and migration as well dramatically down-regulated pSTAT3, STAT3, N-cadherin, Vimentin, TWIST, MMP-2 and MMP-9 expressions and upregulated E-cadherin expression, while KLF5 level remains unchanged."
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"Specifically, activated STAT3 increases the invasive abilities of BrC cells by initiating the transcription of the MMP2 and MMP9 genes, whereas blocking STAT3 activity suppresses MMP2 and MMP9 expression, tumor invasion, and lung metastasis [XREF_BIBR, XREF_BIBR]."
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"Inhibition of STAT3, FAK and Src reduced the expression of MMP9 which is essential for cell migration and invasion XREF_BIBR (XREF_SUPPLEMENTARY)."
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