IndraLab

Statements

P22077 inhibits USP10. 7 / 7
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"Notably, P22077, HBX19818, and HBX19818 analogs including Compounds 3, 7, and 9 also inhibit USP10 in mutant-FLT3-expressing cells."
35627217
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"Moreover, P22077 still strongly inhibits the viability of USP7 or USP10 stably knockdown K562 cells."
33397955
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"It has been reported that P22077 also inhibits the activity of USP7 and USP10."
33397955
eidos
"P22077 inhibited only USP7 , USP9x , USP10 and USP20 appreciably at 1 muM ( USP47 was not tested ) ."
26852935
eidos
"Along with USP7 , P22077 and HBX19818 has also been reported to inhibit USP10 , promoting degradation of FLT3-mutant AML cells [ 174 ] ."
32354135
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"These results indicate that the combination of cisplatin and USP10 inhibition by P22077 exhibits a more potent inhibition of tumor growth than either single agent treatment, and suggest a novel strategy of combining USP10 inhibition with cisplatin for treatment of NSCLC."
32382008
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"However, a recent study (Weisberg et al., 2017) revealed that P22077 and HBX19818 may also inhibit the deubiquitinase activity of USP10 and induce the proliferation inhibition of mutant-FLT3 (FLT3-ITD)-positive cancer cells."
30319415