IndraLab

Statements

BMPR1A binds USP15. 10 / 13
3 | 5 2
biogrid
No evidence text available
24850914
reach
"The strong interaction between USP15 and ALK3 and their co-localization at the plasma membrane suggested that USP15 could act as a DUB for ALK3."
24850914
reach
"We show that USP15 interacts with SMAD6 and ALK3 and enhances BMP signalling by deubiquitylating ALK3 and rescuing it from proteasomal destruction."
24850914
reach
"Next, we tested how SMAD6 affected the interaction between GFP-USP15 and FLAG-ALK3 (XREF_FIG b)."
24850914
sparser
"The strong interaction between USP15 and ALK3 and their co-localization at the plasma membrane suggested that USP15 could act as a DUB for ALK3."
24850914
biogrid
No evidence text available
24850914
sparser
"SMAD6 overexpression disrupts the association of USP15 with ALK3 and potently inhibits BMP signalling."
24850914
reach
"It was shown that USP15 interacts with type I BMP receptors, including ALK3, co-localises with ALK3 at the membrane and deubiquitylates ALK3, thereby countering the inhibition of the BMP pathway caused by SMAD6 XREF_BIBR."
25007997
biogrid
No evidence text available
24850914
reach
"Here, we demonstrate that USP15 interacts with and deubiquitylates the type I BMP receptor ALK3."
24850914