IndraLab

Statements

USP5 activates cell cycle. 6 / 6
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"It has identified NQQ1 as a potential drug target for host directed tuberculosis therapy, ATP1A1 as a gene that regulates aurilide B cytotoxicity, and the deubiquitinating enzyme, USP5, which modulates cell cycle regulators.34, 35, 36 The shRNA screening system has also identified HIF1alpha as a TERT regulator using mouse ES cells.37 In this study in a HCC cell line, we identified two genes, C15orf55 and C7orf43, as activators of TERT transcription through SP1 and YAP1, respectively."
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"USP5 deficiency also induces DNA damage , cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma cells ( 51 , 53 ) ."
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"These data indicated that USP5 promoted ovarian cancer cell proliferation and cell cycle progression through regulating HDAC2."
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"It is noteworthy that USP5 is highly expressed in Gliomas [XREF_BIBR], where p53 stabilization effect caused due to the accumulation of unanchored polyubiquitin in the absence of USP5 causes cell cycle arrest [XREF_BIBR]."
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"USP5 deficiency also induces DNA damage, cell cycle arrest and apoptosis in pancreatic ductal adenocarcinoma cells."
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"Disruption of USP5 profoundly repressed cell proliferation by inducing cell cycle G0/G1 phase arrest in ovarian cancer cells."
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