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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP7 inhibits TBK1. 2 / 2

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"In addition , USP13 removes K27-linked polyubiquitinchains from STING then decreases the antiviral immune response against DNA viruses by disrupting the recruitment of TBK1 , whereas USP7 removes K48-linked polyubiquitination from TRIM27 and promotes the degradation of TBK1 ."

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"In SeV infection there seems to be another mechanism at work ; the ubiquitin-specific peptidase 7 ( USP7 ) interacts with and stabilizes TRIM27 , promoting the degradation of TBK1 and suppressing the activation of IFN-beta ( Cai et al ., 2018 ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...