IndraLab

Statements

USP7 inhibits TBK1. 2 / 2
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eidos
"In addition , USP13 removes K27-linked polyubiquitinchains from STING then decreases the antiviral immune response against DNA viruses by disrupting the recruitment of TBK1 , whereas USP7 removes K48-linked polyubiquitination from TRIM27 and promotes the degradation of TBK1 ."
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eidos
"In SeV infection there seems to be another mechanism at work ; the ubiquitin-specific peptidase 7 ( USP7 ) interacts with and stabilizes TRIM27 , promoting the degradation of TBK1 and suppressing the activation of IFN-beta ( Cai et al ., 2018 ) ."
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