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USP15 activates NFkappaB. 10 / 10
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"USP15 is also reported to activate NF-kappaB signaling by deubiquitination and stabilization of the transcription factor NF-kappaB p65 , which inhibits apoptosis and induces cell proliferation in multiple myeloma [ 68 ] ."
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"In contrary, another study found no interaction between USP15 and IkappaBalpha, and it was proposed that USP11 inhibits the ubiquitination and degradation of IkappaBalpha in the early stage while USP15 functions at a later time point in the TNFalpha induced NF-kappaB activation XREF_BIBR."
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"Similarly, we observed that increasing quantities of USP15 caused the inhibition of SEV induced activation of ISRE (XREF_FIG), NF-kappaB (XREF_FIG), and IRF3 (XREF_FIG) promoters, additionally, the expression of ISGs."
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"Collectively, USP15 positively regulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by distinct mechanisms, which reflects the potential nonredundant roles of TAB2 and TAB3."
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"Coexpression of increasing amounts of Myc tagged USP15 further enhanced the IFN-beta and NF-kappaB promoter activation stimulated by GST-RIG-I (2CARD) and TRIM25 in a dose dependent manner (XREF_FIG)."
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"Zhou et al. noted that depletion of USP15 in multiple myeloma enhanced the NFkappaB transcriptional activity and reduced the rate of apoptosis."
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"USP15 potentiates NF-kappaB activation by differentially stabilizing TAB2 and TAB3."
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"Overexpression of USP15 potentiated TNFalpha- or IL-1beta-triggered NF-kappaB activation and downstream genes transcription, whereas knockdown of USP15 had opposite effects."
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"As shown in XREF_FIG, co-expression of USP15 enhanced the AP-1, AP-2, AP-3, SP-1 and NF-kappaB signal pathways transactivated by ectopically expressed HBx although these signal pathways were also affected to a lesser extent by USP15 overexpression alone (XREF_FIG)."
28074857
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"However, Sun et al. found no interaction between USP15 and IkappaBalpha, and proposed that USP11 inhibits the ubiquitination and degradation of IkappaBalpha in the early stage, whereas USP15 functions at a later time point in the TNFalpha induced NF-kappaB activation XREF_BIBR."
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