IndraLab

Statements

USP10 increases the amount of HDAC6. 4 / 4
| 4
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"XREF_FIG (lanes 1-7), only wild-type USP10, but not the catalytically deficient mutant (USP10 and C424A), significantly increased the endogenous level of HDAC6, indicating that USP10 's deubiquitinase activity is imperative for increasing the protein level of HDAC6."
32382008
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"Depletion or inhibition of USP10 significantly decreases HDAC6 protein levels, inhibits tumor growth, and increases p53-mutant and null cancer cell sensitivity to cisplatin in a xenograft mouse model."
32382008
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"XREF_FIG, knockdown of USP10 decreased HDAC6 protein levels as compared to the control H23 cells, while MG132 restored HDAC6 expression in the knockdown cells, indicating that blocking proteasome degradation leads to HDAC6 accumulation."
32382008
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"The above results suggest that USP10 up-regulates HDAC6 protein expression, most likely through deubiquitinating and consequently stabilizing HDAC6."
32382008