IndraLab

Statements

USP18 inhibits CD8. 4 / 4
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"In conclusion, lack of Usp18 in CD11c + cells reduced priming of islet specific CD8 + T cells and prevented induction of diabetes."
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"We found here that lack of Usp18 in dendritic cells prevented enforced virus replication and would therefore limit induction of autoreactive CD8 + T cells, but also induction of IFN-I production."
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"Furthermore, in comparison to control mice, the frequency of conventional CD11b + DCs in the spleen of Usp18 -/- mice was reduced by about 50% (XREF_FIG), however, the conventional CD8 + DCs (XREF_FIG) and pDCs (CD11c int B220 + CD11b -) (data not shown) populations were observed with the same frequency in the spleens of both Usp18 -/- and control mice."
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"The absence of Usp18 limited the expansion of virus specific CD8 + T cells (XREF_FIG) and reduced IFN-gamma production by CD8 + T cells (XREF_FIG) and CD4 + T cells (XREF_FIG)."
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