IndraLab

Statements

SREBF2 binds USP28. 11 / 13
2 | 4 7
sparser
"However, it is possible that the interaction between SREBP2 and USP28 is indirect and involves additional, unknown proteins."
37202505
sparser
"It has also been demonstrated that USP28 binds to mature SREBP2, leading to its deubiquitination and stabilization."
39944823
sparser
"While both proteins localise to and interact in the nucleus, we did observe some level of interaction of SREBP2 and USP28 also in the cytoplasm."
37202505
sparser
"Moreover, mature SREBP2 binds to USP28, leading to deubiquitination and stabilization, as well as regulation of the mevalonate pathway (MVP), which drives the synthesis of cholesterol, thus driving tu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38070792
sparser
"Notably, it is unclear whether the interaction between SREBP2 and USP28 is direct or whether it involves additional proteins."
37202505
reach
"However, it is possible that the interaction between SREBP2 and USP28 is indirect and involves additional, unknown proteins."
37202505
reach
"While both proteins localise to and interact in the nucleus, we did observe some level of interaction of SREBP2 and USP28 also in the cytoplasm."
37202505
reach
"Notably, it is unclear whether the interaction between SREBP2 and USP28 is direct or whether it involves additional proteins.USP28 is highly upregulated in LSCC, where it stabilises the transcription factor ΔNP63 that is essential for the maintenance of the squamous lineage [16]."
37202505
reach
"Moreover, mature SREBP2 binds to USP28, leading to deubiquitination and stabilization, as well as regulation of the mevalonate pathway (MVP), which drives the synthesis of cholesterol, thus driving tu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38070792
sparser
"We also show that USP28 binds to mature SREBP2, leading to its deubiquitination and stabilisation."
37202505
sparser
"Studies have discovered an interaction between SREBP2 and USP28, with both co-localizing in the nucleus of LSCC cells."
39544292