IndraLab

Statements

Modified BAP1 decreases the amount of EZH2. 3 / 3
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"Re-expression of BAP1 in Bap1 KO bone marrow cells reduced Ezh2 mRNA expression to normal levels (XREF_SUPPLEMENTARY)."
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"This could represent a possible connection between BAP1 and expression of HLA in uveal melanoma, as study in mice showed that loss of BAP1 leads to increased levels of EZH2 (and PRC2) with repressed expression of its targets [XREF_BIBR], including thus CIITA, leading ultimately to less HLA class II expression."
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"Recurrent BAP1 mutations have also been observed in intrahepatic cholangiocarcinoma 25, and a recent study showed that loss of Bap1 in mice increases expression of H3K27me3 and Ezh2 while suppressing expression of PRC2 targets 26."
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