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"Seeking a possible link between reduced NF-kappaB activation by the E protein and increased inflammasome activation and TNFalpha release , we found that expression of Tnfaip3 ( A20 ) , which is activated by NF-kappaB and mediates important negative feedback on expression of inflammatory genes , was reduced by the E protein in LPS + poly ( I :C ) treated cells ( Supplementary Fig. S4B ) ."