IndraLab

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NFkappaB inhibits TNFAIP3. 6 / 6
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"TNIP1 (also known as A20-binding inhibitor of NF-kB (ABIN)-1) is known for its stimulatory effect on the NFkB inhibiting DUB A20 and inhibition of TNF-induced apoptosis and is upregulated in several types of cancer [ xref ]."
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"The NFkB inhibiting DUB A20 is also involved in TNIP-independent regulation of NFkB signaling [ xref ]."
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eidos
"Seeking a possible link between reduced NF-kappaB activation by the E protein and increased inflammasome activation and TNFalpha release , we found that expression of Tnfaip3 ( A20 ) , which is activated by NF-kappaB and mediates important negative feedback on expression of inflammatory genes , was reduced by the E protein in LPS + poly ( I :C ) treated cells ( Supplementary Fig. S4B ) ."
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"TNIP1 is also able to prevent processing the IkB p105 into p50 [ xref ] and to interact with the NFkB inhibiting DUB A20, stimulating deubiquitination of NEMO, thereby impairing IKK activation and thus canonical NFkB activation [ xref ]."
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"Numerous lines of evidence, from human disease linkage analyses to mouse experimental models, attest to critical roles for the NFκB inhibiting partner proteins A20 and ABIN1 in systemic and cutaneous inflammatory disease."
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"Moreover, Tax requires CADM1 for its K63-linked polyubiquitination, NF-κB activation, and inactivation of the NF-κB negative regulatory A20 complex."
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