IndraLab

Statements

Glu-Ala inhibits NLRP3. 9 / 9
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"XREF_BIBR Our studies further demonstrated that EA not only attenuated NLRP3 inflammasome activation but also suppressed the inflammatory exosome release in emphysema."
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"The EA pretreatment suppressed NLRP3 inflammasome activation, reduced lung edema, and inhibited IL-1beta release into the serum and BALF after CPB."
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"Suppression by EA of NLRP3 Inflammasome Formation and Activation in the Lung of Mice Receiving PPE Instillation."
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"Furthermore, real-time RT-PCR analysis revealed that UA or EA pretreatment significantly suppressed the elevated mRNA levels of inflammation markers NLRP3, IL-1beta, and TNF-alpha in alcohol exposed AML12 cells (XREF_FIG C)."
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"This suggests that EA can attenuate activation of NLRP3 inflammasome in the lung during PPE induced emphysema."
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"EA Treatment Reverses the Robust Upregulated Levels of NLRP3 Inflammasome in the Hippocampus of PS cDKO Mice."
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"XREF_BIBR Moreover, there are reports that EA inhibits NLRP3 inflammasome activation through cannabinoid B2 (CB2) receptors by endocannabinoids in inflammatory pain XREF_BIBR and that ROS and Nrf2 pathway mediates EA induced amelioration of cardiopulmonary bypass induced apoptosis and inflammation in the lung, indicating the role of redox signaling."
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"First, EA reduced NLRP3 inflammasome signaling activation in microglia and subsequent proinflammatory cytokines ' excretion."
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"The present study did not attempt to define the mechanisms by which EA attenuates PPE induced lung NLRP3 inflammasome activation and associated exosome release to induce inflammatory response and degenerative injury."
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