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"In particular, the role of robust DUB activity in promoting viral replication and conferring virulence in CCHFV and SARS-CoV emphasizes the impact of the respective proteases and highlights the emerging importance of understanding their effects when considering potential pathogenicity and therapeutic strategies.With the almost perfectly conserved sequence of Ub, it is not surprising that tick-borne nairoviruses from disparate taxa possess notable DUB activity."