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ND-EZH2 activates USP1. 3 / 3
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"Accordingly, depletion of USP1/EZH2 in GSC11 cells markedly induced G0/G1 phase arrest, and reconstituted overexpression of ND-EZH2 reversed the effect of USP1 depletion on cell cycle distribution (Fig. S5E)."
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"Moreover, depletion of β-catenin/USP1/EZH2 in GSC11 cells markedly decreased cell proliferation, and reconstituted overexpression of ND-EZH2 almost fully reversed the effect of USP1 depletion (Fig.6B and Fig.S5B)."
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"Moreover, overexpression of ND-EZH2 further reversed the effects of USP1/EZH2 depletion on tumor formation (Fig. 6C)."
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