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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP14 deubiquitinates PI3K. 2 / 2

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"Mechanistically, USP14 deubiquitinates and activates PI3K/AKT in HCC cells."

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"In addition, USP14 was observed to upregulate the Wnt/β-catenin signaling mediated by cleaving K63-linked polyubiquitin chains (Table 2, Figure 6) (Jung et al., 2013) (Huang et al., 2015), and promote the proliferation and metastasis of HCC cells by deubiquitinating and activating PI3K (Table 2) (Wright et al., 2019; Zhang Y. et al., 2020)."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...