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USP4 inhibits NFkappaB. 20 / 24
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"Consistent with this, the results of Hou et al. 28 showed that USP4 promotes apoptosis and inhibits NF-kappaB activation in head and neck squamous cell carcinoma."
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"USP4 deubiquitinates TRAF6 and inhibits the TRAF6-stimulated NF-κB reporter gene and regulates the activation of NF-κB ( xref ) ( xref )."
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"USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2."
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"Studies focused on the other USPs demonstrated that USP14 overexpression regulates IkappaB polyubiquitination to stimulate its degradation 26, and ectopic expression of USP4 inhibits the TRAF2- and TRAF6 stimulated NF-kappaB reporter gene and negatively regulates the TNF-alpha-induced IkappaB-alpha degradation and NF-kappaB activation 27."
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"In addition, USP4 inhibits TNF-alpha-induced activation of NF-kappaB through USP4 deubiquitination of TAK1 XREF_BIBR."
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"Therefore, our studies reveal USP4 suppresses p53 and NF-kappaB activation by stabilizing HDAC2."
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"XREF_BIBR showed that USP4 could block Dox induced activation of NF-kappaB at the early stage of the treatment by preventing TAK1 from conjugating K63 linked polyubiquitin chains."
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"USP4 inhibits NF-kappaB transcriptional activity through HDAC2."
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"USP4 inhibits TAK1 and TAB1 co-overexpression-mediated NF-kappaB activation."
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"238 Recently, USP4 has been identified as a new DUB of TRAF6 and can negatively regulate the NF-kappaB signaling pathway."
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"USP4 was identified by studies to negatively regulate both TNF-alpha- and IL-1beta-induced NF-kappaB activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Also, USP4 de-ubiquitinated and then inhibited the activation of p53 and NF-kappaB [XREF_BIBR]."
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"USP4 negatively regulates IL-1beta-induced NF-kappaB activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"To further explore the role of USP4 on NF-kappaB target gene expression, we examined the effect of USP4 knockdown on the expression of other TNFalpha induced NF-kappaB target genes."
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"Recent studies have shown that USP4 serves as a critical control to downregulate NF-κB activation through deubiquitinating TAK1, TRAF2 and TRAF6. xref , xref It has also been reported that HDAC2 could inhibit NF-κB activation. xref , xref In our study we found that HDAC2 could reduce TNFα-induced acetylation of RelA in H1299 cells, but HDAC2 could not interact with RelA ( xref ), consistent with previous studies. xref Therefore, we explored the possibility that USP4 inhibits NF-κB transcriptional activity through HDAC2 using an NF-κB-dependent luciferase reporter gene assay."
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"USP4 acts as a TAK1 Lys63 specific deubiquitinase to deubiquitinate TAK1 and inhibit Dox induced NF-kappaB activation."
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"Recent studies have shown that USP4 serves as a critical control to downregulate NF-kappaB activation through deubiquitinating TAK1, TRAF2 and TRAF6."
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"27 Therefore, we explored the possibility that USP4 inhibits NF-kappaB transcriptional activity through HDAC2 using an NF-kappaB-dependent luciferase reporter gene assay."
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"It was also found that USP4 inhibited NF-kappaB activation, but in this study we confirmed that USP4 positively regulates the NF-kappaB signalling pathway during EV71 infection."
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"Fourth, USP4 inhibits NF-kappaB transcriptional activity through HDAC2."
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