IndraLab

Statements

TNF increases the amount of PTGER4. 16 / 19
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"Specifically, CsA can suppress TNF production without decreasing TNF mRNA, while either dexamethasone or PGE2 block TNF transcription."
2735909
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"Studies have shown that TNF-alpha, along with IFN-gamma, promotes the expression of HGF, PGE2, and COX-2 levels by allogeneic MSCs, contributing to the inhibition of proliferating T lymphocytes [XREF_BIBR]."
26000315
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"Purified human rIL-1 alpha and IL-1 beta increased the levels of both products in the supernatants of the synovial cells; TNF-alpha raised the PGE2 levels but raised the plasminogen activator activity only weakly and inconsistently."
2787354
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"In contrast, TNF-alpha administration markedly increased plasma levels of PGE2 and epinephrine."
8595522
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"IL-1alpha, -1 beta, -6, -8, TNF-alpha, and LPS treatment induced the co-expression of BMP2 and PGE2 in amnion cells."
16157126
isi
"Also, guava significantly enhanced HGEK-16 cell viability (P < 0.05), and IL-beta1, TNFalpha and PGE2 expression presented a 0.6-fold decrease when exposed to guava and LPS (P < 0.05)."
31779134
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"Taken together, our results suggest that TNFalpha induced a switch from the PGD2 to PGE2 synthesis pathway by regulating PGE2 synthase expression and/or activity and that activators of PKA markedly potentiated the TNFalpha induced increase in PGE2 through up-regulation of COX2 gene expression."
9388257
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"Amnion epithelial cells did not release significant amounts of PGE2 in response to TNF (XREF_FIG)."
19109223
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"IL-1 and tumor necrosis factor-alpha (TNF-alpha), both at 1-100 ng/ml, and PTH at 0.1-10 nM increased PGHS-2 and cPLA2 mRNA and medium PGE2 levels dose-dependently after 4 h of treatment."
8852946
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"Cells prestimulated with IL-I \ [~ + BK or TNF-a + BK produced much larger amounts of PGE2 than cells prestimulated with cytokine without BK."
8777276
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"We conclude that (1) IL-1, TNF-alpha, and PTH, but not IL-6 nor IL-11, can increase the expression of PGHS-2, cPLA2, and PGE2 production in cultured mouse calvariae; (2) IL-4 inhibits PGE2 production in both control and stimulated calvarial cultures by inhibiting PGHS-2 and cPLA2; and (3) IL-4 has an inhibitory effect on bone resorption which is independent of PG production."
8852946
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"In the bioactivity assay, PGE2 levels induced by TNFalpha were reduced to an average of 30% using microspheres loaded with 0.1 nmol CXB per transwell; with microspheres loaded with 0.1 nmol TA, PGE2 production was initially reduced to 3% and gradually recovered to 30% reduction."
25163981
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"TNF-alpha stimulation increased the levels of GM-CSF and PGE2 in epithelial cell supernatants and dexamethasone suppressed the TNF-alpha induced increases."
10476324
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"TNF-alpha treatment significantly up-regulated the levels of PGE2, NO, sICAM-1, TGF-beta1, MCP-1, and MIP-1alpha in the supernatants of RASFs, increased the protein expression of COX-2, iNOS, and induced phosphorylation of Akt, IkappaB-alpha, NFkappaB, and ERK1/2 in RASFs."
21511722
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"TP could significantly down-regulate TNFalpha induced COX-2, iNOS expression and production of PGE2, NO in human RASF, which is associated with the suppression of NF-kappaB activity."
15067740
isi
"Moreover, EPS103 reduced the excessive release of IL-6, TNF-alpha, prostaglandin E2 (PGE2), and NO, as well as inhibited the mRNA expression of IL-6, TNF-alpha, cyclooxygenase-2 (COX-2), and inducible NO synthase (iNOS) of RAW264.7 macrophages activated by LPS."
31760015