IndraLab

Statements

reach
"Overexpression studies revealed that viral protease/DUB activity can modulate or block activation of the innate immune response pathway."
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reach
"• Coronaviruses and arteriviruses encode papain-like protease domains that process the replicase polyprotein and are required for viral replication• Many viral papain-like proteases are multifunctional and have protease, deubiquitinating and deISGylating activity• Structural and enzymatic studies revealed the multifunctional nature of coronavirus and arterivirus papain-like proteases• Viral DUB and deISGylating activity is proposed to modulate the innate immune response• An arterivirus papain-like protease has been shown to modulate the innate immune response to viral infection (49) ."
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