IndraLab

Statements

UCHL5 binds HAUS7. 18 / 18
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"We suggest that UIP1 may bind the C-terminal extension of UCH37."
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"Furthermore, it appears that UCH37 binds UIP1 more strongly compared to its binding of S14 as judged by the beta-galactosidase activity.The transcription of the UIP1 gene in human tissues was studied [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Bands of ~ 1000 bp with approximately equal intensity were amplified from multiple tissues when G3PDH was used as a control.We carried out in vitro binding assays to confirm that S14 or UIP1 could ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, UIP1 did not interact with the N-terminal part of UCH37 (the part of UCH37 that includes the UCH catalytic domain)."
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"Furthermore, it appears that UCH37 binds UIP1 more strongly compared to its binding of S14 as judged by the β-galactosidase activity."
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"These results indicate that S14 and UIP1 could bind UCH37 specifically in vitro in a C-terminal extension dependent manner.As the results of experiments using the yeast two-hybrid assay showed that th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This indicates that UCH37 binds UIP1 preferentially and that the binding of S14 by UCH37 may be blocked by UIP1.When using anti-Myc antibody to precipitate the lysates from COS-1 cells co-transfected [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As the results of experiments using the yeast two-hybrid assay showed that the interaction between UIP1 and UCH37 was much stronger than that between S14 and UCH37, it was therefore of interest to det[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This finding suggests that the UIP1 could bind UCH37 via its C-terminal extension in vivo.As the PA700 associated isopeptidase (UCH37) has been shown to edit polyubiquitinated substrates [6,7], it may[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We postulate that UIP1 binds the C-terminal extension of UCH37 preferentially and thus blocks the association of UCH37 with PA700 in the 26S proteasome.The biological functions of UCH37 are still uncl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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biogrid
No evidence text available
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"This indicates that UCH37 binds UIP1 preferentially and that the binding of S14 by UCH37 may be blocked by UIP1."
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biogrid
No evidence text available
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"This finding suggests that the UIP1 could bind UCH37 via its C-terminal extension in vivo."
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biogrid
No evidence text available
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hprd
No evidence text available
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sparser
"The interaction of UCH37 with UIP1 was confirmed by an in vitro binding assay ( Fig. 4 ) and in vivo co-immunoprecipitation analysis ( Fig. 5 )."
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"The interaction of UIP1 with UCH37 is stronger than that of UCH37 with S14 as shown by the results of the yeast two-hybrid assay and the in vitro competitive binding assay."
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