IndraLab

Statements

USP8 increases the amount of USP8. 2 / 2
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"PTEN deficient cells, which have low levels of USP8 and high levels of FLIP S, were relatively TRAIL resistant, and as previously noted, introduction of WT USP8 (but not blank vector or catalytically inactive USP8) increased USP8 levels and significantly increased the extent of TRAIL induced apoptosis (XREF_FIG)."
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"USP8 upregulated YY1 protein level through deubiquitination and YY1 activated USP8 transcription, and USP8-YY1 feedback loop attenuated cognitive dysfunction in SAE mice, which could potentially serve as a novel theoretical foundation for the management of SAE."
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