IndraLab

Statements

USP8 increases the amount of USP8. 5 / 5
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"Repression of deubiquitinase UBPY expression (by ubiquitin isopeptidase Y) exacerbates TDP-43 toxicity in Drosophila, despite the retention of ubiquitin chains [53]."
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"As shown in Fig. 2, USP8 expression was significantly increased in the USP8 group compared with in the NC group, thus indicating successful USP8 overexpression."
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"USP8 upregulated YY1 protein level through deubiquitination and YY1 activated USP8 transcription, and USP8-YY1 feedback loop attenuated cognitive dysfunction in SAE mice, which could potentially serve as a novel theoretical foundation for the management of SAE."
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"PTEN deficient cells, which have low levels of USP8 and high levels of FLIP S, were relatively TRAIL resistant, and as previously noted, introduction of WT USP8 (but not blank vector or catalytically inactive USP8) increased USP8 levels and significantly increased the extent of TRAIL induced apoptosis (XREF_FIG)."
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"Consistently, we observed that IBA1 expression was significantly reduced after LPS administration, and icv injection of USP8 restored microglial USP8 levels ( Fig. 1 B, C)."
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