IndraLab

Statements

Modified HACE1 leads to the ubiquitination of RAC1. 5 / 5
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"The overexpression of HACE1 enhanced Rac1 polyubiquitination compared with control cells, whereas the overexpression of catalytically inactive HACE1 (C876S) showed no change in levels of Rac1 polyubiquitination (XREF_FIG) 16 Moreover, to verify that HACE1 ubiquitylation of Rac1 occurs at lysine 147 (citation), we ectopically expressed HA tagged wild-type Rac1 as well as a K147R mutant."
25659579
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"HACE1 expression increases the ubiquitylation of Rac1, when the GTPase is activated by point mutations or by the GEF-domain of Dbl."
22036506
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"As previously reported, we found that wild-type HACE1 expression increased Rac1 ubiquitylation levels."
28317937
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"Consistent with previous groups, we observed that HACE1 overexpression enhances polyubiquitination of wild-type Rac1 but not the K147R mutant (XREF_FIG)."
25659579
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"HACE1 expression increases the ubiquitylation of Rac1, while RNAi mediated depletion of HACE1 blocks the ubiquitylation of active Rac1 and increases levels of GTP bound Rac1 [XREF_BIBR]."
22572609