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USP18 increases the amount of USP18. 1 / 1

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"As seen in Fig. 6B, HIRI led to a significant increase in LCMV viral titers in USP18+/+ mice, an effect that was not observed in USP18−/− mice.Having shown that LPS/TNF-α stimulation increases hepatocyte USP18 expression, we then sought to determine whether we could pharmacologically inhibit the induction of USP18 by LPS and TNF-α."

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USP18 increases the amount of USP18. 1 / 1

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