IndraLab

Statements

JAK2 phosphorylates JAK2 on tyrosine. 16 / 16
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rlimsp
"In response to angiotensin II, Jak2 autophosphorylates on tyrosine, and Jak2 and STAT1 physically associate, a process that depends on the SH2 domain of STAT1 in vitro."
10748109
rlimsp
"Moreover, at biochemical level, we should have observed a higher basal level of JAK2 auto-phosphorylation on the critical 1007–1008 tyrosine residues."
26413812
reach
"In addition, it has been shown in ovarian cancer and sarcoma cells expressing constitutively active JAK2 that cisplatin significantly inhibited tyrosine phosphorylation and kinase activity of JAK2 in a dose- and time-dependent manner [29]."
31929796
rlimsp
"However, there is only limited knowledge of the physical structure of JAK2 or which of the 49 tyrosines in JAK2 are autophosphorylated."
15143187
reach
"As expected, PRLR and Jak2 activation led to tyrosine phosphorylation of Jak2, PRLR as well as wild type and catalytically inactive form of SHP-2."
12531430
rlimsp
"AG490 and WHI-P154 completely prevented CXCL12-triggered tyrosine autophosphorylation of both JAK2 and JAK3 (Fig. 3, A and B)."
24368807
reach
"Upon binding of leptin to its extracellular domain, homodimerized LepRb undergoes a conformational change that enables the activation of JAK2, which then phosphorylates other tyrosine residues within the LepRb–JAK2 complex to activate downstream signalling cascades (FIG."
28232667
rlimsp
"This suggests that the initial signalling event in GH action is the activation of JAK2 which in turn phosphorylates tyrosines within JAK2 and GH receptor."
9076344
reach
"In particular, we investigated JAK2 tyrosine kinase activation and phosphorylation (and subsequent activation) of STAT1 and STAT3 transcription factors."
17472849
rlimsp
"Characterization of this compound revealed that it inhibits Jak2 tyrosine autophosphorylation in both a time- and concentration-dependent manner."
15801842
reach
"Janus kinase 2 (JAK2) is then activated, resulting in JAK2 autophosphorylation and tyrosine phosphorylation of IL-23R, which in turn result in the recruitment, phosphorylation, homodimerization, and nuclear translocation of signal transducer and activator of transcription 3 (STAT3)."
19006613
reach
"15 (S)-HETE also induced tyrosine phosphorylation of Janus kinase 2 (Jak2) in VSMCs, and its inhibition substantially reduced STAT3 phosphorylation, MCP-1 expression, and VSMC migration."
21536676
reach
"Interestingly, LY294002 enhanced the TPO induced DNA binding activity of Stat5 without affecting the Jak2 activation and tyrosine phosphorylation of Stat5."
11756417
rlimsp
"In summary, we have identified a novel site of Jak2 tyrosine autophosphorylation; namely, tyrosine 201."
17027227
reach
"A 15 min incubation of PRL-naive cells led to substantial tyrosine phosphorylation of Jak 2 and Stat 5a by U-PRL and an essentially equivalent Jak 2 activation by S179D PRL."
12809512
rlimsp
"Ligand-receptor binding leads to activation of the associated JAK2 molecules, resulting in rapid autophosphorylation of multiple tyrosines within JAK2."
15121872