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CYLD inhibits Ubiquitin. 12 / 14
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"Consistent with the notion that NF-kappaB signalling could be turned off through negative feedback mechanism involving CYLD mediated ubiquitin (Ub) deconjugation [XREF_BIBR], the CYLD depletion compromised and CYLD overexpression potentiated cell apoptosis are separately overrided by NF-kappaB inhibitor BAY 11-7085 and IkappaBalpha siRNA."
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"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD and TNFAIP3 and A20 negatively regulate the NFkappaB pathway by removing ubiquitin chains from multiple signaling molecules including TRAFs and RIP."
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"Mechanistically, CYLD removes lysine-63-linked ubiquitin chains from TRAF2, TRAF6, and NEMO, whereas lysine-48-linked ubiquitin chains are not degraded by CYLD."
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"When the deubiquitinating enzymes A20, CYLD, and OTULIN degrade the ubiquitin chain of RIPK1, complex I dissociate, and the released RIPK1 forms the cytoplasmic death-induced signaling complex (DISC), Complex IIa, or complex IIb, inducing programmed cell death (7)."
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"XREF_BIBR Suppression of CYLD by miR-182 promoted ubiquitin conjugation of NFkappaB signaling components and led to sustained NFkappaB activation."
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"CYLD was shown to negatively regulate NF-kappaB and MAPK activation by removing ubiquitin chains from key signalling molecules including NEMO, TRAF2, TRAF6 and RIPK1."
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"Deubiquitinating enzyme CYLD negatively regulates the ubiquitin dependent kinase Tak1 and prevents abnormal T cell responses."
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"CYLD inhibited the activity of the IKK complex by removing the K63 ubiquitin chains on NEMO, the regulatory subunit of the IKK complex."
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"In addition, CYLD negatively regulated NF‐κB activation by deconjugating its k63‐linked ubiquitin chains [87]."
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"This suppression of CYLD promoted ubiquitin conjugation of NF-kappaB signaling pathway components and induction of an aggressive phenotype of glioma cells both in vitro and in vivo."
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"In the presence of MG132, Flag-CYLD remarkably decreased ubiquitin chains of p53 ( Fig. 4 J, Supplementary Fig. S5H )."
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