IndraLab

Statements

CYLD inhibits Ubiquitin. 9 / 11
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"This suppression of CYLD promoted ubiquitin conjugation of NF-kappaB signaling pathway components and induction of an aggressive phenotype of glioma cells both in vitro and in vivo."
23006329
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"CYLD was shown to negatively regulate NF-kappaB and MAPK activation by removing ubiquitin chains from key signalling molecules including NEMO, TRAF2, TRAF6 and RIPK1."
27561390
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"Deubiquitinating enzyme CYLD negatively regulates the ubiquitin dependent kinase Tak1 and prevents abnormal T cell responses."
17548520
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"We further show that CYLD negatively regulates a ubiquitin dependent NF-kappaB activator, RIP1."
17981138
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"Consistent with the notion that NF-kappaB signalling could be turned off through negative feedback mechanism involving CYLD mediated ubiquitin (Ub) deconjugation [XREF_BIBR], the CYLD depletion compromised and CYLD overexpression potentiated cell apoptosis are separately overrided by NF-kappaB inhibitor BAY 11-7085 and IkappaBalpha siRNA."
29050336
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"Mechanistically, CYLD removes lysine-63-linked ubiquitin chains from TRAF2, TRAF6, and NEMO, whereas lysine-48-linked ubiquitin chains are not degraded by CYLD."
14676304
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"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
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"CYLD and TNFAIP3 and A20 negatively regulate the NFkappaB pathway by removing ubiquitin chains from multiple signaling molecules including TRAFs and RIP."
19615732
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"XREF_BIBR Suppression of CYLD by miR-182 promoted ubiquitin conjugation of NFkappaB signaling components and led to sustained NFkappaB activation."
26273328