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IKBKE phosphorylates CYLD on S418. 22 / 22
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sparser
"Conversely, IKKe directly phosphorylates CYLD at Ser418, hereby decreasing its deubiquitinating potential but increasing the IKKeinduced cell transformation [41] (Fig. 3 ) (see Section 6) ."
23333767
sparser
"Taken together, these findings demonstrate that phosphorylation of CYLD by IKKε at serine 418 is necessary for IKKε to fully induce transformation."
19481526
sparser
"Jessica Hutti presented evidence that IKKε can phosphorylate CYLD at Ser418, and that CYLD phosphorylation is required for IKKε-induced transformation of cells in culture."
19287453
sparser
"IKKε and TBK1 are activated upon T cell activation and can directly phosphorylate CYLD at Ser418."
29755980
rlimsp
"We confirmed that CYLD is directly phosphorylated by IKKepsilon and that IKKepsilon phosphorylates serine 418 in vivo. Phosphorylation of CYLD at serine 418 decreases its deubiquitinase activity and is necessary for IKKepsilon-driven transformation."
19481526
rlimsp
"Of these potential substrates, serine 418 of the tumor suppressor CYLD was identified as a likely site of IKKepsilon phosphorylation. We confirmed that CYLD is directly phosphorylated by IKKepsilon and that IKKepsilon phosphorylates serine 418 in vivo. Phosphorylation of CYLD at serine 418 decreases its deubiquitinase activity and is necessary for IKKepsilon-driven transformation."
19481526
sparser
"Conversely, IKKɛ directly phosphorylates CYLD at Ser418, hereby decreasing its deubiquitinating potential but increasing the IKKɛ-induced cell transformation [41] (Fig. 3 ) (see Section 6)."
23333767
reach
"Conversely, IKKepsilon directly phosphorylates CYLD at Ser418, hereby decreasing its deubiquitinating potential but increasing the IKKepsilon induced cell transformation XREF_BIBR (XREF_FIG) (see Section 6)."
23333767
sparser
"IKKε-induced phosphorylation at Ser418 of CYLD decreased its activity ( xref ) and completely blocked CYLD-mediated deubiquitination of TRAF2, thereby promoting tumorigenesis in breast cancer cells ( xref ; xref ; xref )."
34177595
rlimsp
"We confirmed that CYLD is directly phosphorylated by IKKepsilon and that IKKepsilon phosphorylates serine 418 in vivo."
19481526
reach
"The TCR- and PMA/I induced Ser418 phosphorylation of CYLD could be completely prevented by dual inhibition of IKKepsilon and TBK1, using MRT67307, while the IKKbeta inhibitor TPCA1 had no effect."
29755980
sparser
"Conversely, IKKɛ directly phosphorylates CYLD at Ser418, hereby decreasing its deubiquitinating potential but increasing the IKKɛ-induced cell transformation xref ( xref ) (see Section xref )."
23333767
sparser
"The tumor suppressor CYLD is directly phosphorylated by IKKε at serine-418 to decrease its deubiquitinase activity, which is essential to the IKKε-induced transformation [ xref ]."
20863366
sparser
"Further, in an in vitro kinase assay we could show that recombinant IKKε and TBK1 can directly phosphorylate CYLD at Ser418 (Figure xref )."
29755980
reach
"Moreover, IKKepsilon, a noncanonical IKK family member, phosphorylates CYLD at serine 418 and reduces its deubiquitinase activity, leading to induction of oncogenic transformation [XREF_BIBR]."
27844253
reach
"IKKepsilon and TBK1 are activated upon T cell activation and can directly phosphorylate CYLD at Ser418."
29755980
reach
"Our initial data indicated that CYLD is directly phosphorylated by the noncanonical IkappaB kinases (IKKs) IKKepsilon and TANK Binding Kinase 1 (TBK1) at Ser418 upon TCR stimulation."
29755980
sparser
"IKKε-dependent CYLD Ser418 phosphorylation and inactivation of its DUB activity has also been reported in response to stimulation of the C-type lectin receptor DC-SIGN in dendritic cells (Gringhuis et al., xref )."
29755980
sparser
"Moreover, IKKε, a noncanonical IKK family member, phosphorylates CYLD at serine 418 and reduces its deubiquitinase activity, leading to induction of oncogenic transformation [ xref ]."
27844253
sparser
"CYLD is phosphorylated by IKKε at Ser418."
19481526
reach
"Interestingly, immunoprecipitation with the phospho (Ser418)-CYLD antibody, followed by immunoblotting with anti-CYLD, revealed that CYLD is phosphorylated by IKKepsilon and TBK1 at Ser418 upon T cell stimulation, but that its direct detection with the phospho (Ser418)-CYLD-specific antibody in a western blot is masked by another inducible protein of the same size that is recognized by the same antibody."
29755980
reach
"Jessica Hutti presented evidence that IKKepsilon can phosphorylate CYLD at Ser418, and that CYLD phosphorylation is required for IKKepsilon induced transformation of cells in culture."
19287453