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IGF1 binds IGF1R and IRS1. 1 / 1
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"Loss of LAR gene product in a mouse knockout model results in reduced fasting levels of insulin, glucose [ xref ] and IGF-1 [ xref ] alongside elevation of IGF-1 stimulated phosphorylation of IGF-1R, IRS1, IRS1 associated PI3K and extracellular signal related kinase (ERK1/2) activity in vascular smooth muscle cells."