IndraLab

Statements

STUB1 decreases the amount of ATXN3. 4 / 4
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reach
"Also, consistent with effects in non neuronal cells, both CHIP and Parkin decreased Q78 ataxin-3 levels in MN-1 neuronal cells but Mdm2 did not (XREF_FIG)."
18784277
reach
"As a result, silencing of CHIP significantly increases the amount of Atx3 (XREF_FIG), suggesting that CHIP may down-regulate the Atx3 level."
21625540
signor
"Although our data show that CHIP may associate with Atx3 to ubiquitinate Atx3 in vitro, we still wonder whether CHIP is directly involved in the degradation of Atx3.|As a result, silencing of CHIP significantly increases the amount of Atx3 (XREF_FIG), suggesting that CHIP may down-regulate the Atx3 level."
21625540
bel
"For example, overexpression of the human TPR domain-containing co- chaperone CHIP suppresses neurodegeneration in fly models expressing polyQ-containing versions of ataxin 1 and the N-terminal huntingtin fragment (Al-Ramahi et al., 2006)."
27491084