IndraLab

Statements

sparser
"Because the concentrations of PKA inhibitors, Rp-cAMPS and PKI 5-24, used in this study are sufficiently high to inhibit PKA activity completely, H-89-induced inhibition of Kv1.3 does not result from [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11286994
sparser
"We report for the first time that H-89 inhibits Kv1.3 channels, a member of the -type K channel subfamily, by a mechanism which is independent of PKA."
11286994
sparser
"Therefore, the characteristics of Kv1.3 inhibition by H-89 are similar to previous findings of open channel block of Kv1.3 by staurosporine in the same cells ."
11286994
sparser
"We find that H-89 potently inhibits Kv1.3 by a mechanism that is independent of PKA inhibition, and the concentrations required to inhibit Kv1.3 are within the range of those used in physiological exp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11286994