IndraLab

Statements


RAF1 phosphorylates MAP2K1 on S222. 20 / 20
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"Among other effectors, active ras binds and activates the raf kinase, iniziating a kinase cascade involving serine phosporylation of mek1/2 (mapkk) and tyrosine and threonine phosphorylation of erk1/2 ras activation leads to raf and subsequently mek activation. Phospholipide analysis demostrated that serine residues 218 and 222 of human mek1 are the primary sites for phosphorylation by c-raf."

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rlimsp
"This strategy revealed that MEK1 is constitutively and mainly phosphorylated at the Thr-292, Ser-298, Thr-386, and Thr-388 residues in vivo, and that combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. Like the levels of phosphorylation of the Ser-218 and Ser-222 residues by RAF1, which have been well studied, the phosphorylation statuses of Thr-292, Ser-298, Thr-386, and Thr-388 residues vary widely during activation and deactivation of the MAPK pathway."

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reach
"Raf-1 phosphorylates MEK1 on two serine residues, Ser 218 and Ser222 [XREF_BIBR] MEK1 phosphorylates tyrosine and threonine residues in the ERK activation loop."

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reach
"Raf-1, in turn, phosphorylates MEK1 and MEK2 on Ser217/218 and Ser221 residues, respectively."

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