IndraLab

Statements

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"Furthermore, we demonstrate that depletion of USP10 or depriving of its catalytic activity with small‐molecule inhibitor Spautin‐1 significantly represses the metastasis of HCC cells in vitro and/or in vivo, whereas the reconstitution of Smad4 was able to efficiently rescue this defect."
31721429
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"Functionally, USP10 serving as an oncogene potentiates the proliferation and metastasis of HNSCC cells in vitro and in vivo."
40204721
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"As shown in Fig. S5D, the protein levels of USP10 were more abundant and highly correlated with Smad4 expression in tumorous regions compared with that in nontumorous tissues.These results demonstrate that USP10 reinforces the TGF‐β signaling and promotes the metastasis of HCC cells."
31721429
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"Targeting USP10 by shRNA inhibited CRC proliferation and metastasis, and this effect was reversed by overexpression of NLRP7."
33838681
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"In addition, the inhibition of USP10 by spautin-1 significantly suppressed the migration and metastasis of HCC."
35627217
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"The USP10/IGF2BP1 axis promoted BC metastasis in vitro and in vivo."
36632454
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"The results indicated that IGF2BP1 could block BC metastasis caused by USP10 overexpression in vivo (Figure 4J-K)."
36632454
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"USP10 promotes HNSCC metastasis in vitro and in vivo."
40204721
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"Deubiquitinating enzyme USP10 promotes osteosarcoma metastasis and epithelial-mesenchymal transition by stabilizing YAP1 ."
37184153
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"The current study identified the prometastatic roles of USP10 in HCC and found that USP10 promotes TGF‐β signaling and HCC metastasis by stabilizing Smad4 through the cleavage of proteolytic K48‐linked ubiquitination.5 Conclusions."
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"USP10 enhances EMT and distant metastasis of OS."
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"However, other studies have reported that USP10 overexpression promotes tumor metastasis or proliferation in adult T cell leukemia, 40 glioblastoma multiforme, 41 chronic myeloid leukemia, 42 non‐small‐cell lung cancer, 43 and liver cancer."
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"For instance, USP10 promotes tumor metastasis through deubiquitination and stabilization of Smad4 in advanced HCC [8]."
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"For example, USP10 could enhance the proliferation and metastasis of NSCLC by stabilizing HDAC744, whereas USP10 can stabilize p53 and inhibit breast cancer progression 45."
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"Further in vivo and in vitro experiments in this work have shown that high USP10 expression can promote EMT and metastasis in OS cell lines."
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"Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein."
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"Moreover, ablation of USP10 by either shRNAs or USP10 inhibitor Spautin‐1 significantly suppresses the metastasis of HCC cells in vitro and/or in vivo, whereas the reconstitution of Smad4 was able to efficiently rescue this defect, indicating that targeting USP10 could be a novel therapeutic strategy of metastatic HCC displaying high level of Smad4.2 Materials and methods."
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"On the other hand, USP10 overexpression promoted YAP1 expression, improved EMT, and simultaneously increased distant tumor metastasis."
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"These results indicated that USP10 promotes the TNBC metastasis in vitro and in vivo ."
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"Further study demonstrated that USP10 promotes TGF‐β signaling and HCC metastasis through the regulation on the protein abundance of Smad4, but imposing minimal effect on Smad2 and Smad3."
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"USP10 knockdown increased ubiquitination and degradation of YAP1, which further decreased the programmed cell death ligand 1 (PD-L1) and Galectin-9 expression, suppressed immune escape, and reduced the proliferation and metastasis of PAAD cells in vitro and in vivo."
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"The results showed that downregulated USP10 in vivo significantly promoted the metastatic ability of GC cells, including liver metastasis (AGS cells) and lung metastasis (MKN45 cells)."
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"To extend our in vitro observations concerning USP10’s role in promoting HCC metastasis, we evaluated whether USP10 could promote HCC metastasis in vivo."
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"Namely, USP10 inhibition reduced the metastasis of PAAD cells in vivo as well.3.6 Overexpression of Cyr61 enhances immune tolerance of pancreatic adenocarcinoma cells."
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"Taken together, these data suggested that depletion of USP10 significantly inhibits HCC metastasis both in vitro and in vivo."
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"USP10 promotes hepatocellular cancer metastasis by stabilizing Smad4 protein [20]."
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"Inhibition of USP10 by siRNA or the small molecule inhibitor Spautin-1 decreased metastasis of hepatocellular carcinoma in murine models ."
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"HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway."
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"In order to demonstrate that Smad4 indeed involved in the regulation of USP10 promoting HCC metastasis, we investigated whether Smad4 could rescue the metastasis defect caused by USP10 depletion."
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"NLRP7 or USP10 knockdown dramatically inhibited liver metastasis in a mouse model."
33838681
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"In the current study, we found that there was no correlation between expression of TM4SF1 and USP10, S100A12, p53, or Ki67 expression in GC, suggesting that TM4SF1 plays a distinct role in GC invasion and metastasis from those of USP10, S100A12, p53, or Ki67, although they all contribute to cancer invasion and metastasis."
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"USP10 promotes colorectal cancer metastasis through the ZEB1 stabilization (Sun et al. 2023)."
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